2 edition of characterisation of interleukin 7 - sulphated polysaccharide interactions found in the catalog.
characterisation of interleukin 7 - sulphated polysaccharide interactions
Moktar O. GueМЃlleМЃ
Thesis (Ph.D.) - University of Portsmouth, 2002.
|Statement||Moktar O. Guéllé.|
The stromal reaction is a characteristic feature of numerous solid tumours, independent of their malignant capacity. Tumour stroma and tumour fibrotic tissue contain proteoglycans and glycosaminoglycans, often in higher proportion than normal, surrounding tissue .Cited by: Akira, S., Hirano, T., Taga, T., and Kishimoto, T., , Expression of interleukin-2 receptor gamma chain on human neutrophils, FASEB J. – PubMed Google Cited by: 4.
Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological functions that include regulation of immune cell proliferation and by: University, UK, with the title: ‘The interactions of immune cytokines with sulphated polysaccharides. SCIENTIFIC POSITIONS 06 February -present: Lecturer, Division of Biochemistry, Faculty of Medicine, University of Patras. 19 July - 01 February Research Scientist (grade 8, point 7), Sir William Dunn School of.
Pharmaceutical compositions useful for the treatment of interleukin-1 mediated diseases are provided. The pharmaceutical compositions contain interleukin-1 inhibitors and protein stabilizers such as non-ionic surfactants and viscosity enhancers. The addition of a non-ionic surfactant or a viscosity enhancer is effective in stabilizing interleukin-1 inhibitors and, therefore, in pro-longing the Cited by: Cisplatin (cis-diamminedichloroplatinum) is widely used for the treatment of solid malignancies; however, the development of chemoresistance hinders the success of this chemotherapeutic in the clinic. This study provides novel insights into the molecular and phenotypic changes in an isogenic oesophageal adenocarcinoma (OAC) model of acquired cisplatin resistance. Key differences that could be Cited by: 2.
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The characterisation of interleukin 7 - sulphated polysaccharide interactions. (Thesis) Guéllé MO. Publisher: University of Portsmouth  Metadata Source: The British Library Type: Thesis. Abstract.
No abstract supplied. Menu. Formats. Abstract Author: Guéllé Mo. The characterisation of interleukin 7 - sulphated polysaccharide interactions Author: GueÌ lleÌ, Moktar O. Two cytokines, Fms-like tyrosine kinase 3L (Flt3L, also known as Flk2L) and interleukin-7 (IL-7) contribute to murine B lymphopoeisis early and later in life, respectively.
IL-7 is essential for production of human B cells from adult bone marrow and the dependency of B lymphopoiesis on IL-7 becomes progressively more profound during ontogeny (11, 12).Cited by: 2.
In the present study, we employed surface plasmon resonance (SPR) spectroscopy to dissect the binding interactions between GAGs and murine and human forms of interleukin-7 (IL-7). The subpopulation of dendritic cells (DCs) and regulatory T cells (Tregs) from PHPS-treated mice splenocytes were also measured by flow cytometry.
Consistent with previous reports, we showed that PHPS increased the phagocytosis of RAW macrophages, and enhanced the secretion of interleukin (IL)-6, IL and tumor necrosis factor-α (TNF-α).Cited by: The interaction of hIL-7 to heparin displayed a fold and fold faster on- and off-rates compared with the mIL-7/heparin interaction.
The significantly faster kinetic rates for the hIL-7/heparin interaction translate into a fold higher binding affinity than the mIL-7/heparin by: The purified E.
coli-derived interleukin 2 is a monomeric protein of Mr 15 with a sedimentation velocity of S. The amino acid composition of the protein and isoelectric point () are consistent with that part of the translated DNA sequence Cited by: Furthermore, several biological activities of sulphated polysaccharides obtained from red algae, such as antioxidant , anti-inflammatory and antinociceptive , anticoagulant , anticancer.
Molecules that bind recombinant interleukin 1 (rIL-1)β and rIL-1 receptor antagonist (rIL-1ra) with high affinity were detected in sera of healthy individuals. rIL-1β bound with dissociation constants in the nanomolar range, and the serum binding capacity was 40–50 ng/ml.
rIL-1ra bound with 30 times higher affinity, and the serum binding capacity was ng/ml. Rabbit antibodies against Cited by: Interleukin-6 (IL-6) is an example of such a multifunctional cytokine and exerts multiple effects on the immune, hematopoietic and nervous system in a finely regulated interaction with its two receptors: interleukin-6 receptor (IL-6R) and glycoprotein (gp), the component critical for Cited by: 6.
Appasamy, P.,Biological and clinical implications of interleukin-7 and lymphopoiesis, Cytokines Cell Mol Then – Google ScholarCited by: 9. [Frontiers in Bioscience, 1, d] MOLECULAR AND CELLULAR BIOLOGY OF INTERLEUKIN-6 AND ITS RECEPTOR Evan T.
Keller1,2,3,4, Jon Wanagat1, W.B. Ershler1,3 1Glennan Center for Geriatrics and Gerontology, Departments of 2Pathology File Size: KB.
Several immune cytokines, including interleukin-2 (IL-2), interleukin-7 (IL-7) and gamma interferon (INF-γ), have been shown to interact with the sulphated polysaccharides heparin and heparan.
Abstract. Bacterial infections as well as immunological diseases result in activation of various endogenous mediators including cytokines ().One of these cytokines is interleukin-8 (IL-8) which attracts neutrophils, basophils and T-cells, induces adherence to vascular endothelium and extravasation into tissue spaces ().It has been evidenced that the levels of IL-8 in body fluids are elevated Author: Paweł P.
Jagodzinski, Wiesław H. Trzeciak. The binding of IL-8 to sulfated glycosaminoglycans (GAGs) is a crucial step for the regulation of cell adhesion, migration and inflammation.
Due to the great structural diversity of GAGs, a number of important questions concerning the matrix interaction of IL-8 remain by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.
In the present study we characterised these interactions using a series of chemically modified heparins as competitive inhibitors. Human interleukin and p40 homodimer show indistinguishable binding profiles with a panel of heparin derivatives, but that of murine interleukin is by: 3.
Sulfated polysaccharides are capable of binding with proteins at several levels of speciﬁcity. As highly acidic macromolecules, they can bind non-speciﬁcally to any basic patch on a protein surface at low ionic strength, and such interactions are not likely to be physiologically signiﬁcant.
On. Growth factors are potent stimulators or inhibitors of satellite cell proliferation and differentiation. The proper function of some cytokines and growth factors requires an interaction with the cell membrane-associated proteoglycans to enhance the affinity to bind to their primary receptors to initiate downstream signal by: 1.
Interleukin 7 is produced by murine and human keratinocytes. This article has been cited by other articles in PMC. Abstract. Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T cell progenitors and mature peripheral T cells as well.
The structural characterization, antioxidant activity and protective effect against H2O2-induced injury RAW cells of a new polysaccharide (MP1) isolated from Lepidium meyenii Walp. were.Disease description A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5.
Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions.A Biosensor Study Indicating That Entropy, Electrostatics, and Receptor Glycosylation Drive the Binding Interaction between Interleukin-7 and Its Receptor Scott T.